Page 139 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

Cidofovir

• a monophosphate nucleotide analog.
• activated exclusively by host cell kinases and the active diphosphate
inhibits DNA polymerases.

Uses:
• Treatment of cytomegalovirus (CMV)
infections in AIDS patients to treat CMV
retinitis that is unresponsive to other
drugs.

B. Anti-influenza Agents

• There are three related influenza viruses, A, B and C, of which C is relatively

rare and causes only mild infections.

• All three reproduce in the same way

• possess the enzyme neuraminidase which is responsible for liberating the

newly formed virus particles from the host cell.
Oseltamivir- Zanamivir

• There are two neuraminidase inhibitors available
• Oseltamivir: an ethyl ester prodrug for oral administration.
• Zanamivir which is administered by inhalation.

• Both drugs are active against influenza A and B
• Neither drug has activity against other viruses.

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