Page 140 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

• Are most effective if taken within 48 hours of the onset of symptoms
• Reduce the duration of the symptoms by about 1 –

1.5 days.
• Reduce complications in elderly patients or
those with chronic diseases.

• Useful for postexposure prophylaxis of influenza,
but again need to be administered within a few hours of exposure.

Amantadine- Rimantadine

• Prevent uncoating by inhibiting an ion – channel protein (M2 protein)
• treatment of only influenza A infections
• it is effective if given soon after the onset of symptoms

Ribavirin- Respiratory Syncytial Virus (RSV)

• A nucleoside analog that inhibits viral replication by inhibiting viral

mRNA polymerase

• Host cell kinases convert to active monophosphate and triphosphate form

• Indications:

• Treatment of respiratory syncytial virus (RSV) in children.

• Treatment of chronic hepatitis C (HCV) infections in combination with

other antiviral agents.

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