Page 59 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

Classification of preservation

• Based on mechanism of action

1- Antioxidants The agent which prevent oxidation of active pharmaceutical

ingredient which otherwise undergo degradation due to oxidation as they are

sensitive to oxygen. Examples: Vitamin E & C.

2- Antimicrobial agents The agent which active microbes which causes

degradation of pharmaceutical preparation. Examples: Benzoates, Sodium

benzoate, Sorbates.

3- Chelating agents The agents which form the complex with pharmaceutical

ingredient and prevent the degradation of pharmaceutical formulation.

Examples: EDTA, Polyphosphates, Citric acid

• Based on sources:

1. Natural preservatives (Lemon, honey)

2. Artificial preservatives (Benzoate, sorbates)

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