Page 87 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

➢ Many antibiotics (eg, aminoglycosides)

are less active in the low-oxygen, low-pH, and high-protein environment of
abscesses, and drainage of abscesses to enhance antimicrobial efficacy is
recommended when possible.

Antibacterial Agents

Classification

1- Spectrum of activity

Broad spectrum:

• Active against both Gram-positive and Gram-negative organisms.

➢ Tetracyclines, Chloramphenicol, Fluoroquinolones

Narrow spectrum:

• Have limited activity and are primarily only useful against particular species
of microorganisms.

➢ Bacitracin are only effective

against Gram-positive bacteria

➢ Polymixins are usually only
effective against Gram negative

bacteria

2- Effect on bacteria

Bactericidal drugs: kill target organisms (Aminoglycosides, cephalosporins,
Penicillin, Quinolones)

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