Page 91 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book
P. 91
Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)
1- Natural penicillin (Penicillinase-sensitive penicillins)
Benzylpenicillin - Natural
(Penicillin G) - acid sensitive. (parenteral)
Phenoxymethylpenicillin - semisynthetic
(Penicillin V) - stable in acid (oral)
Benzathine benzylpenicillin - slowly absorbed into the circulation, after
(benzathine penicillin) intramuscular injection, and hydrolyzed to
benzylpenicillin in vivo………….
prolonged low concentration (over 2-4
weeks after a single IM dose).
- Prophylaxis of rheumatic fever
Procaine benzylpenicillin - a combination of benzylpenicillin and the
(Procaine penicillin) local anesthetic agent procaine
Spectrum: Gram-positive cocci Streptococci
Some enterococci
Gram-negative cocci Neisseria, Treponema
Anaerobic bacteria Clostridia spp.
Spirochetes Treponema pallidum
Acid sensitive Acid resistant
• Benzylpenicillin (penicillin G) • Phenoxymethylpenicillin
• Benzathine penicillin (Penicillin V)
• Procaine penicillin
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