Page 96 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

Adverse effects of penicillins

❑ Hypersensitivity reactions- most common

- (immediate, accelerated & late allergic reaction)

- skin rashes, fever, Bronchspasm, and

anaphylactic shock

❑ Gastrointestinal upset

- (orally administered preparations)

- Diarrhea, epigastric distress, nausea

- Vomiting, pseudomembranous colitis
❑ Superinfections

- results from alterations in intestinal flora.

- A higher incidence occurs with broad-spectrum penicillins

❑ May cause seizures after high doses by iv or in case of renal failure

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