Page 99 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

2- Cephalosporins

❑ Cephalosporins are grouped into "generations" based on their spectrum of
antimicrobial activity.

❑ Each newer generation of cephalosporins has significantly greater Gram-
negative antimicrobial properties than the preceding generation, in most cases
with decreased activity against Gram-positive organisms.

❑ The newer agents have much longer half-lives resulting in the decrease of dosing
frequency

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