Page 104 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

Imipenem

• Hydrolysed in the mammalian kidney by
Imipenem
dihydropeptidase enzyme

Combined with
Cilastatin dehydropeptidase
inhibitor

Tienam

➢ Imipenem and cilastatin injection is used to treat certain serious infections
(endocarditis and respiratory tract (including pneumonia), urinary tract,
abdominal (stomach area), blood, skin, bone, and joint infections.

Meropenem, Ertapenem

➢ not need to be administered in conjunction
with cilastatin.

➢ Ertapenem has no P. aeruginosa coverage.

Adverse effects
❑ At high doses, imipenem has a high incidence of seizures.
(not with meropenem)

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