Page 102 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

Fourth generation

Cefepime, Cefpirome

• Extended spectrum agents with similar activity against Gram-positive
organisms as first generation cephalosporins

• Excellent activity against Enterobacteriaceae and Pseudomonas
aeruginosa
• Anti-pseudomonal activity = Ceftazidime, Piperacillin/tazobactam
• Greater resistance to beta-lactamases than the third generation

cephalosporins.
• Can cross the blood–brain barrier and are effective in meningitis
• limited activity against anaerobes

• Cefepime is used as Empiric therapy of infection (ventilator-associated

pneumonia)

❑ 4th generation cephalosporins are drugs of last resort for serious
infections

89