Page 103 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

Fifth generation

Extended spectrum
Have Anti-MRSA, enterococci activity
(Teflaro)
Ceftobiprole, Ceftaroline

Active against Pseudomonas No antipseudomonal activity
aeruginosa.

• active against anaerobic Gram-positive bacteria

Adverse effects of Cephalosporins

• Rarely, cause immediate hypersensitivity reactions consisting of rash,
urticaria, or anaphylaxis.

• approximately 5% to 10% of individuals allergic to penicillin will also
have a reaction to cephalosporins

3- Carbapenems

Imipenem, Meropenem, Doripenem, Ertapenem

➢ Resistant to beta-lactamases
➢ The last line of defense against many organisms that are resistant to other
antimicrobial agents.

➢ Broad-spectrum: excellent activity against
✓ aerobic Gram-positive
✓ aerobic Gram-negative,

✓ anaerobic bacteria.
➢ NO ACTIVITY against MRSA

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