Page 101 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

Second generation

Divided into:
True

cephalosporins Cephamycins

cefuroxime cefotetan

cefoxitin

Spectrum:

• Retain some activity against True cephalosporins are more active than
Cephamycins that have limited activity
Gram Positive bacteria against G+ bacteria
• Greater activity against Gram

negative bacteria
• Increased coverage to anaerobe
• More resistant to beta-lactamase

Third generation

Ceftriaxone, Cefotaxime, Ceftazidime

• Wider spectrum of action
nd
• Less active than 2 generation agents against Gram-positive cocci, but
much more active against Enterobacteriaceae
• Can cross the blood brain barrier
• Active against anaerobes

Cefotaxime, ceftriaxone Ceftazidime
• adequate drug levels in CSF……empiric active against Pseudomonas
therapy for bacterial meningitis aeruginosa

• Not active against Pseudomonas It has poor CNS penetration
aeruginosa and should not be used for
meningitis

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