Page 109 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book
P. 109
Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)
• Activity against many aerobic Gram-negative bacteria G -ve bacteria
(P. aeruginosa
• E. coli, Klebsiella spp)
• lacks activity against Gram-positive bacteria, and anaerobic bacteria
➢ Used in treatment of serious infections with multidrug-resistant
Gram-negative bacteria (UTI, skin infection, meningitis)
Toxicity: nephrotoxicity and neurotoxicity
Protein synthesis inhibitors
30s subunit 50s subunit
Aminoglycosides Chloramphenicol
Macrolides
Tetracyclines
Lincosamides
streptogramines
Glycylcyclines Fucidic acid
96
