Page 112 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

Glycylcyclines

• a structurally related class to tetracyclines
• Tigecycline is the only commercially available member

• Broad antimicrobial spectrum active against
➢ aerobic Gram-positive bacteria, including MRSA, VRE
➢ aerobic Gram negative

➢ Good activity against anaerobic bacteria.
➢ Excellent activity against atypical bacteria
➢ NO ACTIVITY against Pseudomonas spp.

(Not affected by food)

Chloramphenicol 50s

Mechanism: binding to the 50S subunit of the ribosome
Chloramphenicol inhibits the bacterial enzyme peptidyl transferase, thereby
preventing the growth of the polypeptide chain during protein synthesis.

Bacteriostatic

99