Page 113 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

➢ Has a broad spectrum of activity against many different categories of
bacteria

➢ One of the most effective antibiotics against anaerobic bacteria
➢ excellent activity against atypical bacteria.

Uses
• Superficial eye infections (bacterial conjunctivitis)
• Bacterial meningitis
• Has been used for Typhoid fever, cholera.

Toxicity:
• Bone marrow suppression => fatal aplastic
anemia
• Gray baby syndrome in neonates

Macrolides 50s

Erythromycin, Clarithromycin, and Azithromycin, Telithromycin
Mechanism: It binds at the P-site of the 50S ribosomal

subunit Bacteriostatic
prevents the transfer of the peptidyl tRNA from the A-site to
the P-site and blocks the protein synthesis

Broad spectrum, active against
- some Gram-positive bacteria
- some Gram-negative bacteria,

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