Page 118 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

Gatifloxacin • community-acquired
Moxifloxacin pneumonia

rd
th
4 Same as 3 generation with • Same as for first-, second-,
broad anaerobic coverage and third-generation agents
Trovafloxacin

Adverse effects:
• gastrointestinal disturbances

• Central nervous system such as headache and dizziness
• Tendon rupture
• Causes cartilage abnormalities,
Avoided, when possible, in children younger than

18 years of age
• Not used at all in pregnant women.
• QT prolongation, increasing the risk of Torsades de

Pointes.

Rifamycins

rifamycin group includes - "classic" rifamycin
-rifamycin derivatives eg: rifampicin (or rifampin), rifabutin.)

Mechanism: act by inhibiting bacterial RNA polymerase block elongation of the
nascent mRNA molecule
Rifampicin (or rifampin)
➢ Usually used in combination with other agents to prevent the emergence of

resistant strains.
- treatment of mycobacterial infections

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