Page 119 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book
P. 119
Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)
❑ note, rifampin causes an orange-red discoloration of
tears, urine, and other body fluids, which can lead to
patient anxiety and the staining of contact lenses
Metronidazole
➢ It is an antiprotozoal drug but also has antibacterial effects on anaerobic
bacteria causing damage of DNA.
➢ metronidazole’s spectrum of activity is limited to obligate anaerobic
bacteria.
Nitrofurans
Nitrofurantoin
Mechanism: of action of nitrofurantoin remains poorly characterized but it is
reduced to toxic intermediate compounds that can interfere
with enzymes in DNA, RNA and protein synthesis. Bactericidal
➢ has activity against many of the organisms that commonly cause urinary tract
infections, including
- aerobic Gram-negative bacteria (except Proteus spp. and P. aeruginosa)
- aerobic Gram-positive bacteria
➢ It is concentrated in urine, so used almost exclusively for the treatment of
urinary tract infections (cystitis)
106
