Page 124 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

• Name the protein synthesis inhibiting antibiotics that act by:
1- binding of 50S subunit to the 30S subunit (ribosome assembly)

2- irreversible binding to 30S subunit leading to misreading of mRNA

3- binding to 30S subunit at the A-site preventing binding of new tRNA

4- binding to 50S subunit of the ribosome and inhibits the bacterial enzyme
peptidyl transferase.

5- binding to 50S subunit of the ribosome at the P-site of the 50S ribosomal
subunit inhibiting the transfer of the peptidyl tRNA (from A to P site)

• Which antibiotics are active only against Gram negative bacteria?

• Which antibiotics are active only against Gram positive bacteria

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