Page 110 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

Aminoglycosides 30s

Streptomycin, Gentamicin, Tobramycin, Neomycin, Amikacin

• Drugs derived from Streptomyces genus ……. suffix –mycin
• Drugs derived from Micromonospora ………suffix -micin

Mechanism: irreversible binding to the 30S subunit causes
• Inhibition of initiation
• misreading of mRNA by ribosomes Bactericidal

• Poor oral absorption (very polar) => parenteral administration (IV, IM) and

topical application

• Excellent activity against aerobic Gram-negative bacteria
(Enterobacteriaceae and Pseudomonas aeruginosa)

• Gentamicin has some activity against aerobic Gram-positive bacteria
• Penetration into cell requires an oxygen-dependent transport => anaerobes

are resistant
• No anaerobic or atypical coverage.

Toxicity

-Nephrotoxicity -Ototoxicity

Dosage: one daily dose

→ To decrease side effects
→ Have concentration dependent killing
→ Have post-antibiotic effect

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