Page 59 - MNU-PM503 Parasitology practical book

Pharm D- Clinical Pharmacy Program Third Level Parasitology and virology (PM503)

Haemo-somatic flagellates (Trypanosoma)

Polymorphic trypanosomes

(T. gambiense, T. rhodesiense):

a- Elongated bodies and multi-sized

(20-30 u. in length).

b- Extra-cellular.

c- Central vesicular nucleus.

d- Posterior kinetoplast.

e- Long undulating membrane.

f- Free flagellum.

Multiple in the blood film.

Definitive host - Tsetse fly

Reservoir host - Man.

Infective stage - Metacyclic trypomastigotes

Mode of infection - Mechanical or direct transmission

- Cyclical transmission

Diagnostic stage - Trypomastigotes

Site of localization - Blood, lymph, lymph nodes, spleen, or

cerebrospinal fluid

Diagnosis

• Detection of parasite in the blood stream, lymph secretions and enlarged lymph

node aspirate provides a definitive diagnosis in early (acute) stages.

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