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9
manufacturer recommended input of 200 ng. Our validation demonstrates that call rate alone
is not sufficient to assess data quality. Heterozygosity and total intensity metrics should be
used in addition to call rate to assess sample quality prior to upload to genealogical
databases.
Author Contributions
David A. Russell: Conceptualization, Methodology, Software, Validation, Formal Analysis,
Investigation, Resources, Data Curation, Writing - Original Draft, Writing - Review & Editing,
Visualization, Supervision, Project Administration.
Erin M. Gorden: Methodology, Validation, Formal Analysis, Investigation, Data Curation,
Writing - Original Draft, Writing - Review & Editing, Visualization.
Michelle A. Peck: Methodology, Validation, Formal Analysis, Investigation, Data Curation,
Writing - Original Draft, Writing - Review & Editing.
Carmen R. Reedy: Conceptualization, Methodology, Writing - Original Draft, Writing - Review
& Editing, Supervision, Project Administration.
Stephen D. Turner: Conceptualization, Methodology, Software, Validation, Formal Analysis,
Investigation, Resources, Data Curation, Writing - Review & Editing.
Christina M. Neal: Conceptualization, Methodology, Writing - Review & Editing, Supervision.
Mary C. Heaton: Conceptualization, Methodology, Writing - Review & Editing, Supervision.
Alexander F. Koeppel: Writing - Review & Editing.
Jessica Bouchet: Methodology, Validation, Investigation.
Elayna Ciuzio: Conceptualization, Methodology, Supervision.
Funding Statement
This work was fully funded by Signature Science, LLC.
Authors Disclosure Statement
The authors DAR, EMG, MAP, CMN, SDT, CRR, MCH, AFK are employees of Signature
Science, LLC. and have no competing financial interests to disclose.
References
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Developmental Validation of the Illumina Infinium Assay using the Global Screening Array (GSA) on the iScan System for use in Forensic Laboratories
