Page 49 - The prevalence of the Val66Met polymorphism in musicians: Possible evidence for compensatory neuroplasticity from a pilot study

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15

100%
100%

90%

80%
80%

Call Rate Concordance 70%

60%

60%

50%

40%

40% 30%
0 125 375 625 1000 0 125 375 625 1000
2
2
Dosage (mJ/cm ) Dosage (mJ/cm )
C NA12878 NA24631 D NA12878 NA24631

Figure 2
(A) Degradation index (DI) values across all dosage intervals. Dosage of 0 mJ/cm indicated control sample with no UV treatment applied. (B) Example of STR
2
electropherograms showing increased degradation with increasing treatment dosages (0, 375, and 1000 mJ/cm ) in a single dye channel. The data was analyzed at a
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minimum analytical threshold of 50 RFU. “No exposure” demonstrates a ‘normal’ distribution of peak heights, while 375 mJ/cm treatment exhibits the ‘ski-slope’ pattern
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typically observed with degraded DNA samples. Treatment at 1000 mJ/cm exhibits the same sloped pattern in addition to allelic drop-out, suggesting greater DNA
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degradation. (C) Call Rates as it relates to the amount of UV dosage. Each line represents a replicate of the two DNA standards used in the study. (D) Sample concordance
of each of the UV-C treated samples as compared back to the 20 ng control sample. Each line represents a replicate of the two DNA standards used in the study.

Developmental Validation of the Illumina Infinium Assay using the Global Screening Array (GSA) on the iScan System for use in Forensic Laboratories