Page 30 - Imprint-magazine june-Issue
P. 30
Clone Selection
Clone selection remains a
critical step in the cell line
development process, as the
choice of clone has significant
impacts on further develop-
ment activities, and is a time
consuming process, poten-
tially involving hundreds of
candidates.
Globally, clone selection is the A one year licence is included for the Ambr® Clone
application most frequently Selection software with every Ambr® 15 Cell Culture
performed on the Ambr® 15, Generation 2 system. This standalone application
and using the system for this solves the problems associated with inconsistent data
purpose has been shown by analysis methods, subjective decision making and the
many biopharma companies burden of manually creating and managing spread-
to significantly reduce time- sheet ranking methods.
lines and increase laborato-
ry productivity. Ambr® 15 Users can now choose between traditional univariate
enables selection of robust methods for analyzing the data that result from clone
clones with high productivity, ranking experiments, and the simplified, streamlined
and optimal product quality multivariate capability provided by the Ambr® Clone
profiles. Selection software.
Ambr® 15 enables New Ambr®
selection of robust Clone Selection
clones with high Powered
productivity by Umetrics®
Perfusion Mimic
Many biopharma companies Existing bench scale The Rapid Vessel Drain
are focussing on intensifica- methods are both time option provides capa-
tion of their work streams, to consuming and expensive bility to bleed large
cut costs, increase produc- to execute, resulting in a volumes of culture and
tivity and ensure consistent demand for a microscale quickly remove spent
product quality. Clones select- solution. media from the Ambr®
ed under fed batch conditions 15 microbioreactors.
may behave differently when New Ambr® 15 Cell Culture The latest Ambr® soft-
transferred to an intensified Generation 2 offers perfu- ware includes novel
process. sion mimic capabilities to process steps to auto-
fast track identification of mate perfusion mimic
clones and media. protocols.
30 JUNE-2021
