Page 31 - Imprint-magazine june-Issue
P. 31

Cell and Gene Therapy




        Ambr® 15 addresses major development bottlenecks, cut timelines and
        deepens scientists’ knowledge of cultivations


        Development teams                   Ambr® 15 offers high               Scientists are using
        are facing significant              throughput experimen-              Ambr® 15 to rapidly
        new challenges, driven              tation to address these            establish protocols for
        by innovations such as              major development                  stable and transient cell
        CAR-T cell therapy. In              bottlenecks, cutting               lines, select suitable
        addition, novel, complex            timelines and deepening            clones, and optimize
        processes must be rapid-            scientists’                        media and processes to
        ly understood in order to           knowledge of cultiva-              facilitate scale up for
        manufacture viral vec-              tions including HEK293,            implementation in new
        tors and next generation            stem cells and immune              manufacturing facilities.
        vaccines on time, and to            derived cell lines.
        the required
        specification.






                           Media and Feed Optimization






                                               Optimizing media and               New mixing steps in the
                                                  feeds can deliver              Ambr® software allow the
                                            important improvements in           creation of media blends in
                                                   cell growth and                 plates on the deck or
                                                     productivity.                     directly in the
                                                                                     microbioreactors.
                                             The Ambr® 15 Cell Culture              Media blends can be
                                                Generation 2 system               defined by volume or as
                                              includes novel functions           percentages. Automated
                                             to streamline and simplify          liquid handling saves time
                                              media, supplement and             and reduces the chance of
                                                 feed investigations.                       error.

























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