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Dalirsani and Seyyedi: CO2 laser on plaque‑like OLP

recurrence rates are reported in different treatment 633 patients from Bucharest, Romania. Med Oral Patol Oral Cir
modalities for OLP lesions. Lichen planus is an Bucal 2013;18:e201-6.
autoimmune condition, in which keratinocyte surface 2. Soliman M, Kharbotly AE, Saafan A. Management of oral
antigens present as targets for cytotoxic cellular lichen planus using diode laser (980 nm): A clinical study.
Egypt Dermatol Online J 2005;1:1-3.
response. Laser therapy destroys keratinocyte surface 3. Richter I, Andabak-Rogulj A, Vučićević-Boras V, Brailo V. Oral
antigens and decreases autoantibodies and lymphocytic lichen planus–Retrospective study of 563 Croatian patients.
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[2]
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for removal of surface antigens is advised. Moreover, in J Oral Maxillofac Surg 2008;46:15-21.
some severe and extended cases, topical therapy may 5. Dalirsani Z, Zenouz AT, Mehdipour M, Alavi F, Javadzadeh Y.
be beneficial. Since some risk factors such as smoking Comparison of the effect of combination of triamcinolone
and alcohol consumption are effective in relapse of acetonide and vitamin A mouthwash with triamcinolone
mouthwash alone on oral lichen planus. J Dent Res Dent Clin
plaque-like lesions, elimination of these risk factors is Dent Prospects 2010;4:21-4.
recommended to decrease the recurrence rate. [27] 6. Chiang C-P, Chang JY-F, Wang Y-P, Wu Y-H, Lu S-Y, Sun A. Oral
Briefly, it seems that laser therapy does not have any lichen planus – differential diagnoses, serum autoantibodies,
side-effect and could be suggested as an alternative hematinic deficiencies, and management. J Formos Med Assoc
2018;117:756-65.
treatment for the OLP lesions, which do not respond to 7. Amirchaghmaghi M, Pakfetrat A, Delavarian Z, Ghalavani H,
conventional treatments. [14] Ghazi A. Evaluation of the efficacy of curcumin in the
treatment of oral lichen planus: A randomized controlled trial.
Conclusions J Clin Diagn Res 2016;10:ZC134-7.
Plaque-like lesion is a keratotic form of OLP, although 8. Delavarian Z, Javadzade-Bolouri A, Dalirsani Z, Arshadi H-R,
is mostly asymptomatic, it needs some interventions Toofani-Asl H. The evaluation of psychiatric drug therapy on
oral lichen planus patients with psychiatric disorders. Med
to decrease the risk of malignant transformation. Laser Oral Patol Oral Cir Bucal 2010;15:e322-7.
therapy is a recently recommended strategy for removal 9. El Shenawy HM, Eldin AM. A comparative evaluation of
of the plaque-like lesions. low-level laser and topical steroid therapies for the treatment
of erosive-atrophic lichen planus. Open Access Maced J Med
With respect to minimal side-effects and appropriate Sci 2015;3:462-6.
comfort level for the patients and physicians, laser 10. Cafaro A, Albanese G, Arduino PG, Mario C, Massolini G,
therapy could be suggested, especially for refractory Mozzati M, et al. Effect of low-level laser irradiation on
and extensive lesions, for which surgery has some unresponsive oral lichen planus: Early preliminary results in
difficulties. 13 patients. Photomed Laser Surg 2010;28(Suppl 2):S99-103.
11. Jajarm HH, Falaki F, Mahdavi O. A comparative pilot study
Declaration of patient consent of low intensity laser versus topical corticosteroids in the
The authors certify that they have obtained all treatment of erosive-atrophic oral lichen planus. Photomed
appropriate patient consent forms. In the form the Laser Surg 2011;29:421-5.
patient(s) has/have given his/her/their consent for 12. Trehan M, Taylor CR. Low-dose excimer 308-nm laser
his/her/their images and other clinical information for the treatment of oral lichen planus. Arch Dermatol
2004;140:415-20.
to be reported in the journal. The patients understand 13. Agha-Hosseini F, Moslemi E, Mirzaii-Dizgah I. Comparative
that their names and initials will not be published and evaluation of low-level laser and CO2 laser in treatment of
due efforts will be made to conceal their identity, but patients with oral lichen planus. Int J Oral Maxillofac Surg
anonymity cannot be guaranteed. 2012;41:1265-9.
14. Van der Hem P, Egges M, Van der Wal J, Roodenburg J. CO2
Acknowledgments laser evaporation of oral lichen planus. Int J Oral Maxillofac
The authors would like to extend their appreciation to Surg 2008;37:630-3.
the vice chancellor for research of Mashhad University 15. Georgakopoulou E, Troupis T, Troupis G, Gorgoulis V. Update
of Medical Sciences for approving and supporting this of the cancer-associated molecular mechanisms in oral lichen
study. planus, a disease with possible premalignant nature. J BUON
2011;16:613-6.
Financial support and sponsorship 16. Machado A, Sugaya N, Migliari D, Matthews R. Oral lichen
planus. Clinical aspects and management in fifty-two Brazilian
Nil. patients. West Indian Med J 2004;53:113-7.
Conflicts of interest 17. Calazans TA, de Campos PH, Melo A-V-G, Oliveira A-V-A,
There are no conflicts of interest. Amaral S-F, Diniz M-B, et al. Protocol for low-level laser
therapy in traumatic ulcer after troncular anesthesia: Case
report in pediatric dentistry. J Clin Exp Dent 2020;12:e201-3.
References 18. Riek C, Vitruk P. Incision and coagulation/hemostasis depth
1. Tovaru S, Parlatescu I, Gheorghe C, Tovaru M, Costache M, control during a CO2 laser lingual frenectomy. Dent Sleep
Sardella A. Oral lichen planus: A retrospective study of practice 2018:32-8.

702 Indian Journal of Dermatology | Volume 66 | Issue 6 | November-December 2021