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THERAPEUTIC ROUND

Treatment of Plaque‑Like Oral Lichen Planus with CO2 Laser

Zohreh Dalirsani, Seyyed Amir Seyyedi 1

Abstract From the Oral and Maxillofacial
Background: Oral lichen planus (OLP) is a chronic autoimmune disease, which annoys the Diseases Research Center, Mashhad
patients for several years. It presents with various clinical forms. Although plaque-like form University of Medical Sciences,
1
of OLP is usually asymptomatic, it could transform to a malignant lesion. Therefore, treatment Mashhad, Department of Oral and
considerations are essential to reduce the development of oral cancer. Laser therapy is a newer Maxillofacial Medicine, Urmia
Dental School, Urmia University of
modality for treatment of plaque-like lesions. Aims: This study aimed to perform laser therapy Medical Sciences, Urmia, Iran
for plaque-like lesions of OLP. Methods: We described some plaque-like OLP lesions evaporated
with CO2 laser. The power of 4–7 watt as continuous wave (CW) and defocused mode was
employed for evaporation. The complications and recurrence were evaluated in the follow-up Address for correspondence:
sessions. Results: In some patients, mild keratotic lesions were observed in the follow-up Dr. Seyyed Amir Seyyedi,
Department of Oral and
sessions. Most patients were satisfied with treatment process and reported mild burning after Maxillofacial Medicine, Urmia
treatment. No complication was observed in the patients. Conclusion: CO2 laser could be Dental School, Urmia University
employed for OLP lesions; however, some degrees of recurrence may occur. of Medical Sciences, Urmia, Iran.
E-mail: seyyediamir@yahoo.com
KEy wordS: CO2 Laser, laser therapy, lichen planus, oral

Introduction corticosteroids, immunosuppression drugs, retinoid,
Lichen planus is an autoimmune mucocutaneous natural substances, psychiatric treatments, and laser
[5-9]
disease, which manifests as various clinical features in therapy.
oral mucosa. The exact mechanism is not clear, T-cell The effects of laser therapy on OLP lesions have been
[1]
mediated immunological process is effective in this reported in the previous studies; however, in most
condition. [1,2] literatures, the low-level laser therapy was considered as
The most cases of OLP were reported among patients who a suggestive treatment plan. [2,9-12]
are in the sixth and seventh decades of their life. [1,3] OLP Furthermore, some researchers evaporate the OLP lesions
is more prevalent in the females than the males. [1,3] through CO2 laser. [13,14]
The typical presentation of OLP is as a bilateral keratotic Finding new strategies for improvement of patients’
white striae. Keratotic types consist of reticular, signs and symptoms is a medical challenge for clinicians.
annular, popular, and plaque-like are the most common Photodynamic therapy is a relatively new modality,
forms of OLP; however, other manifestations including which is considered as main or adjunctive method for
ulcerative, atrophic/erosive, or bullnose lesions are OLP treatment. With respect to what is mentioned
observed in some patients. [1,4] Some clinical features above, we treated some plaque-like OLP lesions with
such as ulcerative and plaque-like lesions have greater CO2 laser and evaluated the results and complications of
susceptibility for transformation to oral SCC. Plaque-like this treatment.
lesions, although are not common presentations of
OLP, respect to possibility of malignant transformation Materials and Methods
[3]
of this form, need special consideration and accurate Oral examination was performed for all patients by
and regular follow-up examinations. an oral and maxillofacial medicine specialist. When
Despite some progression in recent years, there is plaque-like OLP was diagnosed through oral assessment,
not a definitive treatment for OLP and most patients an incisional biopsy was done for confirming OLP.
suffer from its symptoms for several years. Different
modalities are suggested for treatment of OLP, including
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How to cite this article: Dalirsani Z, Seyyedi SA. Treatment of plaque‑like
DOI: 10.4103/ijd.ijd_1170_20 oral lichen planus with CO2 laser. Indian J Dermatol 2021;66:698‑703.
Received: December, 2020. Accepted: September, 2021.

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