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Mansoura National University
Pharm D-Clinical Pharmacy Program Level 1 Pharm. Anal. Chem. 1 (PC 101)
3. Displacement (Substitution) Titration
❖ In this type, a very weak acid or base is displaced from its salt by
a strong acid or base.
❖ Typical examples include the titration of sodium carbonate or sodium borate (borax)
against standard HCl.
Na CO + 2 HCl → 2 NaCl + H O + CO
2 3 2 2
HCl (strong acid) displaces carbonic acid (very weak acid) in its salt
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