Page 18 - PBA Medicine list - edition 5_SW_Neat

By Zarrineh Norouzi and Nisha

Generic Name: Adrenaline

Brand names: EpiPen, Aspen Adrenaline Injection

Side effects/precautions:

Inflammation, sepsis in proposed inj region; cerebral arteriosclerosis; amide-type anaesthetic,
sympathomimetic amine, sulfite hypersensitivity. High dose, CV disease (eg angina pectoris,
degenerative heart disease), cerebrovascular insufficiency.
.
Interactions:

Antiarrhythmic drugs, Amiodarone and Quinidine.

Reasons for interactions:

Antiarrhythmic drugs: it should be used with caution in patients receiving antiarrhythmic drugs e.g.
mexiletine, or any other agents structurally related to local anaesthetics, since potentiation of cardiac
effects may occur.

Amiodarone : This combination has been reported to precipitate seizures and to lead to severe sinus
bradycardia and a long sinoatrial arrest. Until more experience with concurrent use of lidocaine
(lignocaine) and amiodarone becomes available, patients receiving the combination should be
monitored carefully.

17