Page 32 - PBA Medicine list - edition 5_SW_Neat

By Vinya Andriannalis

Generic Name: Oxycodone Hydrochoride

Brand names: Endone

Side effects/precautions:

High dose, prolonged use; abrupt withdrawal; acute asthma, COAD, decr pulmonary reserve,
respiratory depression; acute abdominal conditions; myasthenia gravis; hypothyroidism;
adrenocortical insufficiency; renal, hepatic impairment; prostatic hypertrophy; hypovolaemia; shock;
obstructive bowel disorders; elderly, debility; pregnancy, lactation; children (should not use).
Interactions:

Acidifying/ alkalinising agents; anticholinergics; CNS depressants incl other opioid agonist analgesics,
general anaesthetics, tranquillizers (eg phenothiazines), sedative/ hypnotics, TCAs, hydroxyzine,
alcohol; antihypertensives esp ganglionic blockers; opioid antagonists (incl naloxone, naltrexone),
mixed agonist/ antagonists (incl pentazocine, butorphanol, buprenorphine); metoclopramide;
neuromuscular blockers; coumarins; CYP3A4, CYP2D6 inhibitors (theoretical)

Reasons for interactions:

Oxycodone may potentiate hypotensive effects when used concurrently with antihypertensive
agents, especially ganglionic blockers, leading to increased risk of orthostatic hypotension.

Mixed agonist/ antagonist analgesics (including pentazocine, butorphanol, buprenorphine) may
reduce the analgesic effect of oxycodone and/or may precipitate withdrawal symptoms. Naloxone,
naltrexone antagonize the analgesic, CNS and respiratory depressant effects of oxycodone and
precipate withdrawal symptoms. Dosage of the antagonist agents should be carefully titrated when
used to treat opioid overdosage in dependent patients.

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