Page 44 - PBA Medicine list - edition 5_SW_Neat

By Elise Smithers

Generic Name: Amitriptyline hydrochloride

Brand names: Elavil, Endep, Vanatrip

Side effects/precautions:

Tachycardia; palpitation; A-V block; MI; orthostatic hypotension; somnolence; tremor; dizziness;
headache; drowsiness; aggression; confusion; decr libido; agitation; hyperhidrosis; nasal congestion;
dry mouth; GI upset; speech, micturition disorder; erectile dysfunction; fatigue; thirst; oedema;
hyperpyrexia; weight gain; QT prolongation; serotonin syndrome; withdrawal symptoms; convulsion,
bone marrow depression, blood dyscrasia; suicidality, hepatitis (rare); TdP (very rare)

Interactions:

Guanethidine; other antidepressants incl SSRIs eg fluoxetine, sertraline, paroxetine; anticholinergics;
sympathomimetics incl adrenaline; neuroleptics; CYP2D6 inhibitors (incl cimetidine, quinidine),
substrates (incl phenothiazines, flecainide); CNS depressants incl alcohol, barbiturates; disulfiram;
antithyroids, thyroid hormones; tramadol; Na valproate (monitor); serotonergics; drugs affected by
delayed gastric emptying (eg levodopa), decr intestinal motility (eg anticoagulants)

Reasons for interactions:

Not provided

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