Page 46 - PBA Medicine list - edition 5_SW_Neat
P. 46
By Bassam Bashir
Generic Name: Lorazepam
Brand names: Ativan
Side effects/precautions:
Withdrawal should be gradual as there may be a build up of dependance (4wk-4mth suggested). As a
benzodiazepine, lorazepam may further trigger depression as well as symptoms in schizophrenic
patients. impraired respiratory function. epiepsy. possible abuse. impaired use of machinery and
driving. dizziness, sedation, cotton mouth, eye function disturbances.
Interactions:
Use of this drug with alcohol or CNS depressants should be avoided. It is recommended that patients
be observed for altered responses when benzodiazepines and anticonvulsants are prescribed
together, and that serum level monitoring of the drug.
Reasons for interactions:
The benzodiazepines, including Ativan, produce additive CNS depressant effects when
coadministered with other medications which themselves produce CNS depression.
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