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CLINICAL PRACTICE GUIDELINES              MANAGEMENT OF BIPOLAR DISORDER (2ND ED.)



                         ICD-11                        DSM-5-TR
                                                       DSM-5-TR
             6A62 Cyclothymia  ICD-11       F34.0 Cyclothymic disorder
                         ICD-11
                                                       DSM-5-TR
               6A62 Cyclothymia               F34.0 Cyclothymic disorder
             6A62 Cyclothymia               F34.0 Cyclothymic disorder


             A persistent instability of mood over a period of  At least two years (for children, a full year) of both

               A persistent instability of mood over a period of  At least two years (for children, a full year) of both
             at least two years, involving numerous periods of  hypomanic  and  depressive  symptoms  without
             A persistent instability of mood over a period of  At least two years (for children, a full year) of both
             at least two years, involving numerous periods of  hypomanic  and  depressive  symptoms  without
             hypomanic  and  depressive  symptoms  that  are  ever fulfilling the criteria for an episode of mania,
             at least two years, involving numerous periods of  hypomanic  and  depressive  symptoms  without
             hypomanic  and  depressive  symptoms  that  are  ever fulfilling the criteria for an episode of mania,
             present during more of the time than not, but not  hypomania or major depressive disorder.
             hypomanic  and  depressive  symptoms  that  are  ever fulfilling the criteria for an episode of mania,
             sufficient to meet the full criteria for an episode.      hypomania or major depressive disorder.
             present during more of the time than not, but not
             present during more of the time than not, but not  hypomania or major depressive disorder.
               sufficient to meet the full criteria for an episode.
                                            Specify

             sufficient to meet the full criteria for an episode.      Specify
                                            With anxious distress
                                            With anxious distress
                                            Specify
             Mixed Episode                  Mixed features
                 Mixed Episode              With anxious distress
                                              Mixed features
             Mixed Episode                  Mixed features


             A  mixed  episode  is  characterised  by  the  Manic  or  hypomanic  episode,  with  mixed

               A  mixed  episode  is  characterised  by  the  Manic  or  hypomanic  episode,  with  mixed
             presence of several prominent manic and several  features
             A  mixed  episode  is  characterised  by  the  Manic  or  hypomanic  episode,  with  mixed
             prominent depressive symptoms consistent with    features
             presence of several prominent manic and several
             presence of several prominent manic and several  features
             prominent depressive symptoms consistent with
             those  observed  in  manic  episodes  and  Full  criteria  are  met  for  a  manic  or  hypomanic
             those  observed  in  manic  episodes  and
             prominent depressive symptoms consistent with    Full  criteria  are  met  for  a  manic  or  hypomanic
             depressive  episodes,  which  either  occur  episode, and at least three depressive symptoms
             those  observed  in  manic  episodes  and  Full  criteria  are  met  for  a  manic  or  hypomanic
             depressive  episodes,  which  either  occur  episode, and at least three depressive symptoms
             simultaneously or alternate very rapidly.
                                            are present.
             depressive  episodes,  which  either  occur  episode, and at least three depressive symptoms
             simultaneously or alternate very rapidly.
                                              are present.
             simultaneously or alternate very rapidly.   are present.

                                            Depressive episode, with mixed features
                                              Depressive episode, with mixed features

                                            Depressive episode, with mixed features

                                            Full criteria are met for a depressive episode, and
                                              Full criteria are met for a depressive episode, and
                                            at  least  three  manic/hypomanic  symptoms  are
                                            Full criteria are met for a depressive episode, and
                                            at  least
                                            present.   three  manic/hypomanic  symptoms  are
                                            present.
                                            Rapid cycling
             Rapid cycling                  at  least  three  manic/hypomanic  symptoms  are
                                              Rapid cycling
               Rapid cycling                present.
             Rapid cycling                  Rapid cycling


             High frequency of mood episodes (at least four)  At least four mood episodes in the previous 12

               High frequency of mood episodes (at least four)  At least four mood episodes in the previous 12
             over the past 12 months        months that met the criteria for manic, hypomanic
             High frequency of mood episodes (at least four)  At least four mood episodes in the previous 12
                                            months that met the criteria for manic, hypomanic
               over the past 12 months
                                            or major depressive episodes.
             over the past 12 months
                                            months that met the criteria for manic, hypomanic

                                            or major depressive episodes.
            An interval of at least two months free of symptoms is required to distinguish between

                                            or major depressive episodes.
            An interval of at least two months free of symptoms is required to distinguish between
            episodes.
            An interval of at least two months free of symptoms is required to distinguish between
            episodes.

            episodes.

            Source:
              Source:
            1.  ICD-11 International Classification of Diseases 11th Revision. The global standard for diagnostic
            Source:   International Classification of Diseases 11th Revision. The global standard for diagnostic
            1.  ICD-11
              health information (Available at: https://icd.who.int/).
            1.  ICD-11 International Classification of Diseases 11th Revision. The global standard for diagnostic
              health information (Available at: https://icd.who.int/).
            2.  American  Psychiatric  Association.  Bipolar  and  Related  Disorders.  In  Diagnostic  and  Statistical
              health information (Available at: https://icd.who.int/).
            2.  American  Psychiatric  Association.  Bipolar  and  Related  Disorders.  In  Diagnostic
              Manual of Mental Disorders, Fifth Edition, Text Revision. Washington DC: APA; 2022.  and  Statistical
            2.  American  Psychiatric  Association.  Bipolar  and  Related  Disorders.  In  Diagnostic  and  Statistical
              Manual of Mental Disorders, Fifth Edition, Text Revision. Washington DC: APA; 2022.

                       Manual of Mental Disorders, Fifth Edition, Text Revision. Washington DC: APA; 2022.























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