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CLINICAL PRACTICE GUIDELINES MANAGEMENT OF BIPOLAR DISORDER (2ND ED.)
Appendix 4
Appendix 4
Appendix 4
Appendix 4
Appendix 4
LIST OF SCREENING TOOLS IN BIPOLAR DISORDER
LIST OF SCREENING TOOLS IN BIPOLAR DISORDER Appendix 4
Appendix 4
LIST OF SCREENING TOOLS IN BIPOLAR DISORDER
Appendix 4
LIST OF SCREENING TOOLS IN BIPOLAR DISORDER
LIST OF SCREENING TOOLS IN BIPOLAR DISORDER Appendix 4
Specificity
LIST OF SCREENING TOOLS IN BIPOLAR DISORDER
Rater
No. of
Cut-off
Screening
Comments
Screening No. of Rater Cut-off Sensitivity Specificity Comments
Sensitivity
LIST OF SCREENING TOOLS IN BIPOLAR DISORDER
LIST OF SCREENING TOOLS IN BIPOLAR DISORDER
Sensitivity
Screening
tool
points
items
points
tool No. of Rater Cut-off Specificity Comments
items
Specificity
Comments
No. of
Screening
LIST OF SCREENING TOOLS IN BIPOLAR DISORDER
Cut-off
Sensitivity
Rater
Screening No. of Rater Cut-off Sensitivity Specificity Comments
items
tool
points
Self-
Specificity Screens for lifetime history
17
70%
Mood
Comments mments history of of
80%
Co lifetime
Cut 7 7
Mood No. of Rater Cut-off -off Sensitivity Specificity 70% Screens for
Self-
80%
17
No. of
Screening
Screening
Rater
Sensitivity
tool
items
points
tool
points
items
17
Screens for lifetime history of
70%
Self-
80%
Mood
rated
Cut-off -
(range 3
Comments was no
(hypo) mania. There
disorder
Screening
No. of
rated
disorder
tool items Rater points 7 Sensitivity Specificity (hypo) mania. There was no
(range 3 -
tool
points
items
70%
17
Screens for lifetime
(hypo) mania. There history
7 7
Self-
Mood
80%
Specificity Screens for lifetime history of of
17
Self-
80%
Mood No. of Self- Self- (range 3 80% 80% 70% 70% evidence of a difference in in
70%
Comments was no
Sensitivity
Cut-off -
Screening
disorder
rated
Rater
tool tionnaire
ques
7)
evidence of a difference
7)
points
questi
Mood onnaire
items
Screens for lifetime
7 7
Screens for lifetime history of history of
17 17
Mood
evidence of a difference no
(hypo) mania. There was
disorder
(range 3 -
rated
ques
tool tionnaire
rated
(range 3 -
disorder items rated (range 3 - 7) 80% 70% (hypo) mania. There was no in
points
(MDQ)
disorder
diagnostic accuracy
diagnostic accuracy between
Screens for lifetime between
Mood
(hypo) mania. There was no history of
17
7
(MDQ)
Self-
disorder
(hypo) mania. There was
evidence of a difference no
evidence of a difference in in
7)
questionnaire
questionnaire 17 rated (range 3 - 80% 70% evidence of a difference in between
7)
Mood
(MDQ)
diagnostic accuracy
7
Screens for lifetime history of
Self-
Asian and non-Asian studies
questionnaire
7)
rated
(hypo) mania. There was no
disorder
(range 3 -
Asian and non-Asian studies
questionnaire
evidence of a difference in
7)
diagnostic accuracy between
(MDQ)
(MDQ)
diagnostic accuracy between
(MDQ)
for both the MDQ and HCL-32.
(hypo) mania. There was no 1
evidence of a difference in
7)
Asian and non-Asian studies
questionnaire
diagnostic accuracy between
for both the MDQ and HCL-32.
(MDQ) rated (range 3 - diagnostic accuracy between 1
disorder
Asian and non-Asian studies
Asian and non-Asian studies 1
for both the MDQ and HCL-32.
questionnaire
Asian and non-Asian studies
evidence of a difference in
7)
diagnostic accuracy between
Hypomania
Screens for lifetime history
32
Self-
57%
14
Screens for lifetime history of of
(MDQ)
82%
Hypomania 32 Self- 14 82% 57% for both the MDQ and HCL-32. 1 history 1 1
Asian and non-Asian studies
for both the MDQ and HCL-32.
diagnostic accuracy between
14
57%
Hypomania
Self-
32
for both the MDQ and HCL-32. of
(MDQ)
82%
(range 7 -
checklist
Screens for lifetime significantly
hypomania. More
Asian and non-Asian studies
rated
checklist
rated
for both the MDQ and HCL-32.
Screens for lifetime history of of
Hypomania
14 14
Screens for lifetime history
Self-
82%
Hypomania
32
Hypomania 32 32 Self- rated (range 7 - 82% 82% 57% 57% hypomania. More significantly 1
Self-
14
(range 7 -
57% Screens for lifetime history of significantly
hypomania. More
(HCL-32)
checklist
Asian and non-Asian studies 1
accurate than MDQ to detect
(HCL-32) 32 rated (range 7 - 82% 57% accurate than MDQ to detect 1
18)
for both the MDQ and HCL-32.
18)
Self-
14
Hypomania
hypomania. More significantly significantly of
Screens for lifetime history
rated (range 7 -
(range 7 -
checklist
rated
checklist
hypomania. More
hypomania. More significantly
accurate than MDQ to detect
for both the MDQ and HCL-32.
(HCL-32)
checklist
18)
BD II in mental
hypomania. More healthcare
Screens for lifetime history of
Hypomania
Self-
14
(range 7 -
checklist
accurate than MDQ significantly
(HCL-32) 32 rated 18) 18) 82% 57% BD II in mental healthcare
accurate than MDQ to detect to detect
(HCL-32)
(HCL-32)
accurate than MDQ to detect
18)
BD II in mental healthcare
82%
14
Screens for lifetime history of
57%
Self-
32
Hypomania
centre.
accurate
2 2
centre.
hypomania. More
rated
checklist
(range 7 -
2 than MDQ significantly
(HCL-32)
18)
BD II in mental healthcare to detect
centre. in mental healthcare
BD II
BD II in mental healthcare
hypomania. More significantly
(HCL-32)
19
86%
Bipolar
18)
13
69%
Self-
checklist
accurate than MDQ to detect
Uses
Uses 19 sentences describing
13
Bipolar 19 rated (range 7 - 69% 86% centre. 2 BD II 19 sentences describing
2 2 in mental healthcare
Self-
centre.
Self-
Bipolar
(HCL-32)
accurate than MDQ to detect
centre. 19 sentences describing
13
spectrum
Uses 2 in mental of of
BD II
rated
manifestations
bipolar
Uses 19 sentences describing healthcare
spectrum 19 19 Self- rated 13 18) 69% 69% 86% 86% manifestations bipolar
centre.
Bipolar
of describing
Self-
Bipolar
13
69%
19
86%
Uses 19 sentences
spectrum
rated
Self-
manifestations
Bipolar 19 rated 13 69% 86% manifestations 2 3 3 of bipolar bipolar
Uses 19 sentences describing
BD II in mental healthcare
disorder.
centre.
spectrum c
diagnosti
Uses 19
disorder.
diagnostic
Self-
2 3 sentences describing
Bipolar
manifestations
bipolar
rated
spectrum
spectrum 19 rated 13 69% 86% manifestations of of bipolar
diagnostic
centre.
disorder. 3 disorder.
scale (BSDS)
diagnostic
13
Uses 19
scale (BSDS)
Self-
86%
Bipolar
19
3 3 sentences describing
69%
manifestations
spectrum
disorder.
diagnostic
diagnostic 19 rated 13 88% 80% disorder. of bipolar
scale (BSDS) )
scale (BSDS
86%
69%
Bipolar
Uses 19 sentences describing
Self-
spectrum
Rapid mood
Self-
Validated for BD I only.
manifestations
of
4 4
80%
rated
88%
bipolar
6 6
Rapid mood
Validated for BD I only.
Self-
diagnostic
disorder.
3
scale (BSDS)
scale (BSDS) 6 6 Self- Self- 4 4 88% 88% 80% 80% RMS is significantly better than
Validated for BD I only.
Validated for BD I only.
Rapid mood
rated
of
bipolar
Rapid mood
spectrum
manifestations
disorder.
screener
diagnostic
RMS is significantly better than
rated
screener
rated
3
scale (BSDS)
88%
Self-
80%
Validated for BD I only.
Rapid mood
screener
Self-
Rapid mood 6 6 rated 4 4 88% 80% RMS is significantly better than 4 4
Validated for BD I only.
diagnostic
screener
rated
RMS is significantly better than
disorder.
3
scale (BSDS)
Validated for BD I only.
MDQ in the following:
(RMS)
(RMS) 6 rated 4 88% 80% MDQ in the following: 4
Self-
Rapid mood
rated
screener
MDQ in the following: 4 cantly better than
RMS is signifi
RMS is significantly better than
screener
(RMS)
MDQ in the following:
(RMS)
scale (BSDS)
88%
80%
Validated for BD I only.
1. sensitivity/specificity
4
Self-
6
Rapid mood
1. sensitivity/specificity
screener
RMS is significantly be
Validated for BD I only.
(RMS)
MDQ in the following:
1. sensitivity/specificity
(RMS)
Rapid mood
Self-
1. sensitivity/specificity
2. brevity
4tter than
2. brevity
RMS is significantly be
rated
screener
MDQ in the following:
(RMS) 6 rated 4 88% 80% MDQ in the following: 4 4tter than
2. brevity 1. sensitivity/specificity
2. brevity
1. sensitivity/specificity
screener
RMS is significantly better than
rated
3. practicality
(RMS)
4
MDQ in the following:
1. sensitivity/specificity
3. practicality
2. brevity
2. brevity
3. practicality
MDQ in the following:
(RMS) 3. practicality 4
4. easy scoring
4. easy scoring scoring
1. sensitivity/specificity
4. easy
2. brevity
3. practicality
3. practicality
4. easy scoring
High score suggests
1. sensitivity/specificity likelihood
2. brevity
Bipolarity
Clinician
90%
50
91%
High score suggests
Clinic
Bipolarity
Bipolarity 5 5 5 Clinicianian 50 50 91% 91% 90% 90% High score suggests likelihood likelihood
3. practicality
4. easy scoring
4. easy scoring
Clinician
Bipolarity
2. brevity
High score suggests likelihood
of a true bipolar diagnosis. agnosis.
-rated
3. practicality
of a true bipolar di
index (BI)
index (BI)
index (BI) 5 -rated 50 91% 90% of a true bipolar diagnosis.
-rated
4. easy scoring
Bipolarity
91%
50
Clinician
High score suggests likelihood
90%
Bipolarity 5 5 Clinician 50 91% 90% Score 50: BD
High score suggests likelihood
3. practicality
of a true bipolar diagnosis.
-rated
index (BI)
Score 50: BD
4. easy scoring
Score 50: BD
High score suggests likelihood
Bipolarity
index (BI)
of a true bipolar diagnosis.
-rated
-rated
index (BI) 5 Clinician 50 91% 90% of a true bipolar diagnosis.
Score 50: BD
90%
4. easy scoring k of likelihood
5
Bipolarity
Score 40 -
Score 40 - 50: at ris 50: at risk of
91%
50
Clinician
High score suggests at risk
Score 40 - 50:
of a true bipolar diagnosis. of
index (BI) 5 Clinician 50 91% 90% conversion to BD, thus 50: at risk of
-rated
Score 50: BD
Score 50: BD careful
Bipolarity
High score suggests likelihood
Score 40 - to BD, thus careful
-rated
conversion
of a true bipolar diagnosis.
index (BI)
Score 50: BD BD, thus careful
conversion to
Score 40 - 50: at risk
of a true bipolar diagnosis. of of
Score 40 - 50: at risk
index (BI) -rated monitoring. 5 5 5 5 - 50: at risk of
conversion to BD, thus careful
Score 50: BD
monitoring.
monitoring.
Score 40
conversion
Score 50: BD BD, thus careful
monitoring.
conversion to to BD, thus careful
5 - 50:
Score 40
1 monitoring. to BD, at risk of
conversion
Only monitoring. 5 done thus careful
in
study
Score 40 - 50: at risk of
done
1 1
Only
conversion study
Only
monitoring. to BD, thus careful
5 study
unselected clinical patients. done in in
in
study
Only
done
conversion to BD, thus careful
unselected clinical patients.
1 5
unselected clinical patients. in in
monitoring.
1 1
Only
5 study
done
monitoring. study
done
Only
unselected clinical patients. in
study
done
1
Only
Reference: unselected clinical patients.
unselected clinical patients.
done
1
1. Wang YY, Xu DD, Liu R, et al. Comparison of the screening ability between the 32-item Hypomania study
Only
Reference:
Reference: unselected clinical patients. in
done
1
Only
in
study
Reference:
unselected cl
Checklist (HCL-32) and the Mood Disorder Questionnaire (MDQ) for bipolar disorder: A meta-inical patients.
1. Wang YY, Xu DD, Liu R, et al. Comparison of the screening ability between the 32-item Hypomania
1. Wang YY, Xu DD, Liu R, et al. Comparison of the screening ability between the 32-item Hypomania
Reference:
Reference: unselected clinical patients.
1. Wang YY, Xu DD, Liu R, et al. Comparison of the screening ability between the 32-item Hypomania
Reference: (HCL-32) and the Mood Disorder Questionnaire (MDQ) for bipolar disorder: A meta-
Checklist
Checklist (HCL-32) and the Mood Disorder Questionnaire
analysis and systematic review. Psychiatry Res. 2019;273:461-466. (MDQ) for bipolar disorder: A meta-
1. Wang YY, Xu DD, Liu R, et al. Comparison of the screening ability between the 32-item Hypomania
1. Wang YY, Xu DD, Liu R, et al. Comparison of the screening ability between the 32-item Hypomania
2. Carvalho AF, Takwoingi Y, Sales PM, et al. Screening for bipolar spectrum disorders: A A meta-
Checklist (HCL-32) and the Mood Disorder Questionnaire (MDQ) for bipolar disorder:
analysis and systematic review. Psychiatry Res. 2019;273:461-466.
Reference:
analysis and systematic review. Psychiatry Res. 2019;273:461-466.
1. Wang YY, Xu DD, Liu R, et al. Comparison of the screening ability between the 32-item Hypomania
Checklist (HCL-32) and the Mood Disorder Questionnaire (MDQ) for bipolar disorder: A meta-
Checklist
Reference: (HCL-32) and the Mood Disorder Questionnaire (MDQ) for bipolar disorder: A meta-
comprehensive meta-analysis of accuracy studies. J Affect Disord. 2015;172:337-46.
analysis and systematic review. Psychiatry Res. 2019;273:461-466. bipolar spectrum disorders: A
2. Carvalho AF, Takwoingi Y, Sales PM, et al. Screening for
2. Carvalho AF, Takwoingi Y, Sales PM, et al. Screening for
1. Wang YY, Xu DD, Liu R, et al. Comparison of the screening ability between the 32-item Hypomania
analysis and systematic review. Psychiatry Res. 2019;273:461-466. for bipolar disorder: A meta- A
Checklist (HCL-32) and the Mood Disorder Questionnaire (MDQ) bipolar spectrum disorders:
3. Ghaemi SN, Miller CJ, Berv DA, et al. Sensitivity and specificity of a new bipolar spectrum diagnostic
1. Wang YY, Xu DD, Liu R, et al. Comparison of the screening ability between the 32-item Hypomania A
analysis and systematic review. Psychiatry Res. 2019;273:461-466. bipolar spectrum disorders:
2. Carvalho AF, Takwoingi Y, Sales PM, et al. Screening for
comprehensive meta-analysis of accuracy studies. J Affect Disord. 2015;172:337-46.
comprehensive meta-analysis of accuracy studies. J Affect Disord. 2015;172:337-46.
analysis and systematic review. Psychiatry Res. 2019;273:461-466. for bipolar disorder: A meta-
Checklist (HCL-32) and the Mood Disorder Questionnaire (MDQ)
scale. Journal of affective disorders. 2005;84(2-3):273-7. Screening for bipolar spectrum disorders:
2. Carvalho AF, Takwoingi Y, Sales PM, et al.
Checklist (HCL-32) and the Mood Disorder Questionnaire (MDQ) for bipolar disorder: A meta- A A
2. Carvalho AF, Takwoingi Y, Sales PM, et al. Screening for bipolar spectrum disorders:
comprehensive meta-analysis of accuracy studies. J Affect Disord. 2015;172:337-46.
analysis and systematic review. Psychiatry Res. 2019;273:461-466.
3. Ghaemi SN, Miller CJ, Berv DA, et al. Sensitivity and specificity of a new bipolar spectrum diagnostic
3. Ghaemi SN, Miller CJ, Berv DA, et al. Sensitivity and specificity of a new bipolar spectrum diagnostic
2. Carvalho AF, Takwoingi Y, Sales PM, et al. Screening for bipolar spectrum
comprehensive meta-analysis of accuracy studies. J Affect Disord. 2015;172:337-46. disorders: A
4. McIntyre RS, Patel MD, Masand PS, et al. The Rapid Mood Screener (RMS): a novel and pragmatic
comprehensive meta-analysis of accuracy studies. J Affect Disord. 2015;172:337-46.
3. Ghaemi SN, Miller CJ, Berv DA, et al. Sensitivity and specificity of a new bipolar spectrum diagnostic
scale. Journal of affective disorders. 2005;84(2-3):273-7.
analysis and systematic review. Psychiatry Res. 2019;273:461-466. bipolar spectrum disorders: A
2. Carvalho AF, Takwoingi Y, Sales PM, et al. Screening for
scale. Journal of affective disorders. 2005;84(2-3):273-7.
comprehensive meta-analysis of accuracy studies. J Affect Disord. 2015;172:337-46.
screener for bipolar I disorder. Current Medical Research and Opinion. 2021;37(1):135-44.
3. Ghaemi SN, Miller CJ, Berv DA, et al. Sensitivity and specificity of a new bipolar spectrum diagnostic
3. Ghaemi SN, Miller CJ, Berv DA, et al. Sensitivity and specificity of a new bipolar spectrum diagnostic
scale. Journal of affective disorders. 2005;84(2-3):273-7.
2. Carvalho AF, Takwoingi Y, Sales PM, et al. Screening for bipolar spectrum disorders: A
4. McIntyre RS, Patel MD, Masand PS, et al. The Rapid Mood Screener (RMS): a novel and pragmatic
comprehensive meta-analysis of accuracy studies. J Affect Disord. 2015;172:337-46.
4. McIntyre RS, Patel MD, Masand PS, et al. The Rapid Mood Screener (RMS): a novel and pragmatic
5. Aiken CB, Weisler RH, Sachs GS. The Bipolarity Index: a clinician-rated measure of diagnostic
3. Ghaemi SN, Miller CJ, Berv DA, et al. Sensitivity and specificity of a new bipolar spectrum diagnostic
scale. Journal of affective disorders. 2005;84(2-3):273-7.
scale. Journal of affective disorders. 2005;84(2-3):273-7.
comprehensive meta-analysis of accuracy studies. J Affect Disord. 2015;172:337-46.
4. McIntyre RS, Patel MD, Masand PS, et al. The Rapid Mood Screener (RMS): a novel and pragmatic
screener for bipolar I disorder. Current Medical Research and Opinion. 2021;37(1):135-44.
3. Ghaemi SN, Miller CJ, Berv DA, et al. Sensitivity and specificity of a new bipolar spectrum diagnostic
screener for bipolar I disorder. Current Medical Research and Opinion. 2021;37(1):135-44.
confidence. J Affect Disord. 2015;177:59-64.
scale. Journal of affective disorders. 2005;84(2-3):273-7.
4. McIntyre RS, Patel MD, Masand PS, et al. The Rapid Mood Screener (RMS): a novel and pragmatic
screener for bipolar I disorder. Current Medical Research and Opinion. 2021;37(1):135-44.
4. McIntyre RS, Patel MD, Masand PS, et al. The Rapid Mood Screener (RMS): a novel and pragmatic
3. Ghaemi SN, Miller CJ, Berv DA, et al. Sensitivity and specificity of a new bipolar spectrum diagnostic
5. Aiken CB, Weisler RH, Sachs GS. The Bipolarity Index:
5. Aiken CB, Weisler RH, Sachs GS. The Bipolarity Index: a clinician-rated measure of diagnostic
scale. Journal of affective disorders. 2005;84(2-3):273-7. a clinician-rated measure of diagnostic
4. McIntyre RS, Patel MD, Masand PS, et al. The Rapid Mood Screener (RMS): a novel and pragmatic
screener for bipolar I disorder. Current Medical Research and Opinion. 2021;37(1):135-44.
screener for bipolar I disorder. Current Medical Research and Opinion. 2021;37(1):135-44.
scale. Journal of affective disorders. 2005;84(2-3):273-7. : a clinician-rated measure of diagnostic
5. Aiken CB, Weisler RH, Sachs GS. The Bipolarity Index
confidence. J Affect Disord. 2015;177:59-64.
confidence. J Affect Disord. 2015;177:59-64.
4. McIntyre RS, Patel MD, Masand PS, et al. The Rapid Mood Screener (RMS): a novel and pragmatic
screener for bipolar I disorder. Current Medical Research and Opinion. 2021;37(1):135-44.
5. Aiken CB, Weisler RH, Sachs GS. The Bipolarity Index: a clinician-rated measure of diagnostic
5. Aiken CB, Weisler RH, Sachs GS. The Bipolarity Index: a clinician-rated measure of diagnostic
confidence. J Affect Disord. 2015;177:59-64.
4. McIntyre RS, Patel MD, Masand PS, et al. The Rapid Mood Screener (RMS): a novel and pragmatic
screener for bipolar I disorder. Current Medical Research and Opinion. 2021;37(1):135-44.
5. Aiken CB, Weisler RH, Sachs GS. The Bipolarity Index: a clinician-rated measure of diagnostic
confidence. J Affect Disord. 2015;177:59-64.
confidence. J Affect Disord. 2015;177:59-64.
screener for bipolar I disorder. Current Medical Research and Opinion. 2021;37(1):135-44.
confidence. J Affect Disord. 2015;177:59-64.
5. Aiken CB, Weisler RH, Sachs GS. The Bipolarity Index: a clinician-rated measure of diagnostic
5. Aiken CB, Weisler RH, Sachs GS. The Bipolarity Index: a clinician-rated measure of diagnostic
confidence. J Affect Disord. 2015;177:59-64.
confidence. J Affect Disord. 2015;177:59-64.
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