Page 65 - e-book CPG - Bipolar Disorder

CLINICAL PRACTICE GUIDELINES MANAGEMENT OF BIPOLAR DISORDER (2ND ED.)

For long acting injectable, consider reduce the dose to 300mg once with dose of 400mg once monthly

REMARKS monthly if there are adverse reactions

COMMON/SIGNIFICANT ADVERSE EFFECTS GI: Nausea, vomiting, constipation, xerostomia ENT: tinnitus Endocrine and metabolic: weight gain, hypertriglyceridaemia, hypercholesterolaemia, hyperglycaemia CNS: drowsiness, extrapyramidal reaction, headache, insomnia Hematologic: neutropenia CNS

HEPATIC DOSE No dosage adjustment necessary Child-Pugh class C: Use is contraindicated Child-Pugh class C: Use not recommended 51

RENAL DOSE No dosage adjustment necessary No dosage adjustment necessary CrCl <30 ml/min: Use not recommended

DOSING GUIDE Acute mania or episodes with mixed features, acute hypomania and maintenance treatment Oral - 10 - 15 mg once daily; increase dose in 5 - 10mg/day increment at intervals of >1 week (Max dose: 30 mg/day) LAI - 400 mg once monthly Acute mania or episodes with mixed features Oral

MEDICATION ANTIPSYCHOTICS Aripiprazole Asenapine Cariprazine

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