Page 69 - e-book CPG - Bipolar Disorder

CLINICAL PRACTICE GUIDELINES MANAGEMENT OF BIPOLAR DISORDER (2ND ED.)

REMARKS ● Oral dose needs to be taken with a ● Only oral forms are registered under
REMARKS ● Oral dose needs to be taken with a meal (>500 calories) to be adequately absorbed meal (>500 calories) to be adequately absorbed NPRA ● Only oral forms are registered under

COMMON/SIGNIFICANT ADVERSE EFFECTS COMMON/SIGNIFICANT ADVERSE EFFECTS Endocrine and metabolic: Endocrine and metabolic: weight gain weight gain onstipation, indigestion, GI: c GI: constipation, indigestion, nausea nausea CNS: akathisia, dizziness, CNS: akathisia, dizziness, ction, extrapyramidal

HEPATIC DOSE HEPATIC DOSE No dosage adjustment provided in the No dosage adjustment manufacturer’s provided in the labelling. Use with manufacturer’s caution as it labelling. Use with undergoes extensive hepatic metabolism undergoes extensive and systemic exposure hepatic metabolism may be

RENAL DOSE usual indication- specific dose caution as it liver disease 4. MOH Clinical Pharmacy Working Committee. Clinical Pharmacokinetics Pharmacy Handbook. 2nd ed. Petaling Jaya: Pharmacy Practice & Development 5. PDSB. Quest3+ Product Search Sistem Pendaftaran Produk & Perlesenan (Available at: http
RENAL DOSE usual indication- No dosage specific dose No dosage ustment is adj necessary adjustment is necessary No dosage adjustment No dosage necessary adjustment necessary 2. Clinical Drug Information, Inc. Wolters Kluwer. UpToDate® [Mobile application software].

DOSING GUIDE (Max dose: 50 mg every 2 Acute mania, acute episodes with mixed features and acute Initial: 40 mg twice daily; increase to 60 or 80 mg twice daily. If indicated, maximum recommended dose may be reached as early as Day 2 of (Max dose: 80 mg twice daily) Acute depressive episode Initial:

DOSING GUIDE (Max dose: 50 mg every 2 weeks) Acute mania, acute episodes with mixed features and acute hypomania Oral - Initial: 40 mg twice daily; increase to 60 or 80 mg twice daily. If indicated, maximum recommended dose may be treatment. reached as early as Day 2 of SELECTIVE SEROTONIN

MEDICATION weeks) Ziprasidone hypomania Oral - treatment. Fluoxetine Oral - mg/day) Source: Source: Division, MOH; 2019.
MEDICATION Ziprasidone 55
Fluoxetine