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CLINICAL PRACTICE GUIDELINES              MANAGEMENT OF BIPOLAR DISORDER (2ND ED.)
                             of      receiving   to   become
              Appendix 9   Appendix 9   cases   occurred,   of   cases   but  but   women   receiving   women   reason   a   is   it  it  alternate  drug  may  be   to   reason   not  not   a   data   more   become   data   more




                      NOT RECOMMENDED DURING LACTATION.  NOT RECOMMENDED DURING LACTATION.  newborn or preterm infant due to limited information available.   cessation   lactation   cessation   lactation  gynecomastia and galactorrhea have also been reported.  infants whose mothers were taking aripiprazole.   infants whose mothers

                    LACTATION   LACTATION  An  alternate  drug  may  be  preferred,  especially  while  nursing  a  An  alternate  drug  may  be  preferred,  especially  while  nursing  a  newborn or preterm infant due to limited information available.  Aripiprazole  can  lower  serum  prolactin  in  a  dose-related  manner.  Arip













                                      Cases   of  of   Cases             Manufacturer’s   Manufacturer’s        asenapine   asenapine   If  If             alternate   An   alternate   An   available.    available.            Monitoring:        o  Monitoring:   o          
                           the   the    in   in
                           aripiprazole,   aripiprazole,  first  trimester  if  possible,
                 SUMMARY OF MEDICATIONS FOR BIPOLAR DISORDER WITH PREGNANCY AND LACTATION      asenapine   asenapine  toxic   SUGGEST   SUGGEST   60
                   SUMMARY OF MEDICATIONS FOR BIPOLAR DISORDER WITH PREGNANCY AND LACTATION      60

                           with   with   of   use   the   of   use   the   DATA   DATA   ANIMAL
                      HUMAN DATA SUGGEST LOW RISK.  HUMAN DATA SUGGEST LOW RISK.    Aripiprazole crosses placenta.     Aripiprazole crosses placenta.      requires   requires  mother’s  condition   condition  lowest  effective  dose,  avoiding  the   no  adequate   adequate   are  no  effects were found in animal studies.  effect
                    PREGNANCY   PREGNANCY    Due  to  limited  data,  avoid  use  in  pregnancy.  However,  if  the  Due  to  limited  data,  avoid  use  in  pregnancy.  However,  if  the   treatment   treatment  lowest  effective  dose,  avoiding  the  first  trimester  if  possible,     NO HUMAN DATA -  ANIMAL DATA SUGGEST MOD













                                 mother’s   should be used.   should be used.              RISK.   RISK.  are      There     There      foetus.   foetus.      RISK.   RISK.         RISK.   RISK.         LIMITED   LIMITED        MODERATE RISK   


                    MEDICATION   MEDICATION  Aripiprazole*   Aripiprazole*   Asenapine*   Asenapine*      Cariprazine*   Cariprazine*   Clozapine*   Clozapine*   Haloperidol*   Haloperidol*


                                                     ANTIPSYCHOTICS   ANTIPSYCHOTICS

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