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CLINICAL PRACTICE GUIDELINES              MANAGEMENT OF BIPOLAR DISORDER (2ND ED.)


                          of   quetiapine   receiving   to   of   in   become   of   and   receiving   used   to   receiving   to   of   sedation,   become   become   receiving   to   become
            Appendix 9    cases   occurred,  exposed but   to   Appendix 9   women   that  Appendix 9   rea  a   not   is   it   have  especially  while  nursing  a   cases   but   occurred,   have ne during lactation.   reported   been   data   more  but   cases   occurred,   Appendix 9   movements   women   are   APs   other   r




                    NOT RECOMMENDED DURING LACTATION.  POSSIBLE TO USE DURING LACTATION.   cessation   lactation   follow-up   long-term  indicates that infants generally developed normally.  infants whose mothers were taking aripiprazole.   **Relative Infant Dose (RID): 0.7 - 8.3%.   labelling  especially if other APs are used co

                  LACTATION  LACTATION  An  alternate  drug  may  be  preferred,  especially  while  nursing  a  newborn or preterm infant due to limited information available.  Aripiprazole  can  lower  serum  prolactin  in  a  dose-related  manner.  First- or second-choice agent during breastfeeding.   infants   of  have  gyneco













                                   Cases   Limited of            **RID: 0.02 - 0.1%.         Monitoring:      Manufacturer’s   o      asenapine   If                    Aripiprazole  can         of   Cases         Aripiprazole         alternate   An   of   Cases   available.          o      respiratory
                         the   a     in   may   the   the   in   in   the   in
                         aripiprazole,     aripiprazole,   aripiprazole,   treatment  aripiprazole,   in  ANIMAL  trimester  if  possible,
               SUMMARY OF MEDICATIONS FOR BIPOLAR DISORDER WITH PREGNANCY AND LACTATION      planning       SUMMARY OF MEDICATIONS FOR BIPOLAR DISORDER WITH PREGNANCY AND LACTATION         asenapine    SUMMARY OF MEDICATIONS FOR BIPOLAR DISORDER WITH PREGNANCY AND LACTATION      which  if  the       SUMMARY OF MEDICATIONS FOR B

                         with   woman   a   in   of   use   the   levels   prolactin   with   with   of   use   the  PREGNANCY  SUGGEST MODERATE   of   use   the   with   DATA   of   use   the   DATA  for  use  in  pregnancy;  however,  if   DATA   ANIMAL   DATA   ANIMAL   DATA   ANIMAL
                    HUMAN DATA SUGGEST LOW RISK.  Aripiprazole crosses placenta.      requires   condition  Quetiapine crosses placenta.   AAPs   with  pregnancy, use of quetiapine may be considered.   adequate   no  HUMAN DATA SUGGEST LOW RISK.  effects were found in animal studies.  Aripiprazole crosses placenta.     Risperidone
                  PREGNANCY  PREGNANCY  COMPATIBLE - MATERNAL BENEFIT >> EMBRYO-FOETAL  Due  to  limited  data,  avoid  use  in  pregnancy.  However,  if  the   treatment  lowest  effective  dose,  avoiding  the  first  trimester  if  possible,   needed   is   NO HUMAN DATA -  ANIMAL DATA SUGGEST MODERATE   PREGNANCY   from   data











                        RISK.    mother’s   should be us treatment ed.   If   RISK.   are   There   RISK-    Risperidone   mother’s   lowest   should be used.   mother’s   RISK.   should be used.   RISK.   RISK.   are   There   pregnant  women.   RISK.   are   There   recommende  mother’s  However,  condition   LIMITED   lowest  M
                                                                                                                                                                                                               


                  MEDICATION  MEDICATION   Aripiprazole*   Quetiapine*    Asenapine*      MEDICATION   Risperidone*   Aripiprazole*   MEDICATION   Aripiprazole*   Cariprazine*   Asenapine*   Clozapine*      Asenapine*  MEDICATION      Aripiprazole*   Ziprasidone*   Haloperidol*   Cariprazine*   Cariprazine*   Clozapine*   Asenapin


                                                    ANTIPSYCHOTICS         ANTIPSYCHOTICS   ANTIPSYCHOTICS            ANTIPSYCHOTICS


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