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CLINICAL PRACTICE GUIDELINES MANAGEMENT OF BIPOLAR DISORDER (2ND ED.)
Appendix 5 Appendix 5 REMARKS REMARKS ● Therapeutic Drug Monitoring Steady state: 4 - 5 days ● Therapeutic Drug Monitoring Sampling time: before next morning dose OR 12 hours from Steady state: 4 - 5 days Sampling time: before next morning dose OR 12 hours from Plasma trough concentration (mm
Appendix 5 REMARKS (TDM) o o ● Therapeutic Drug Monitoring (TDM) o last evening dose Steady state: 4 - 5 days o Sampling time: before next Therapeutic range: o morning dose OR 12 hours from last evening dose last evening dose Indication Therapeutic range: o Therapeutic rang
COMMON/SIGNIFICANT ADVERSE EFFECTS COMMON/SIGNIFICANT Cardiac: cardiac arrhythmia, ADVERSE EFFECTS COMMON/SIGNIFICANT T-wave inversion, oedema, ADVERSE EFFECTS hypotension Cardiac: cardiac arrhythmia, CNS: drowsiness, abnormal Cardiac: cardiac arrhythmia, T-wave inversion, oedema, (TDM) EEG,
HEPATIC DOSE HEPATIC DOSE No dosage adjustment No dosage adjustment
RECOMMENDED ADULT MEDICATION DOSAGES AND ADVERSE EFFECTS FOR BIPOLAR DISORDER RECOMMENDED ADULT MEDICATION DOSAGES AND ADVERSE EFFECTS FOR BIPOLAR DISORDER RECOMMENDED ADULT MEDICATION DOSAGES AND ADVERSE EFFECTS FOR BIPOLAR DISORDER HEPATIC DOSE provided in the manufacturer’s labelling N
RENAL DOSE RENAL DOSE CrCl <30 ml/min: RENAL DOSE Use not recommended CrCl <30 ml/min: CrCl <30 ml/min: Use not Use not recommended recommended
DOSING GUIDE DOSING GUIDE Acute mania, acute episodes DOSING GUIDE with mixed features, acute hypomania, acute bipolar Acute mania, acute episodes depression Acute mania, acute episodes with mixed features, acute with mixed features, acute hypomania, acute bipolar hypomania, acute bipolar Initia
MOOD STABILISERS MEDICATION MOOD STABILISERS MOOD STABILISERS Oral - Oral - doses. doses.
MEDICATION MEDICATION Lithium Lithium Lithium
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