Page 85 - e-book CPG - Bipolar Disorder

CLINICAL PRACTICE GUIDELINES MANAGEMENT OF BIPOLAR DISORDER (2ND ED.)

 Only strength 5 mg and 10 mg are registered with NPRA  Commonly seen ADR in paediatric populations: sedation,weight gain, abdominal pain  Fixed dose OFC capsule is not available in Malaysian market  Commonly seen ADR in paediatric populations: somnolence, dizziness, fatigue, incre

REMARKS increased appetite, headache, fatigue, dizziness, dry mouth, nausea, vomiting, dry mouth, May convert at the equivalent total daily dose and administer once daily; individual dosage

HEPATIC Severe impairment: Reduce initial dose. Do not exceed an initial dose of 20 mg daily; (Max dose: 40 mg/day) Use with caution. Dosage adjustment may be necessary; however, no specific recommendations exist. Immediate release 25 mg once daily; titrate by 25 - 50 mg/day to ef

RENAL necessary as not removed by dialysis.
No dosage adjustment is No dosage adjustment is necessary. 71

Acute mania or episodes with mixed features 13 to 17 years old Initial:2.5 - 5 mg once daily weekly interval (Usual target dose: 10 mg/day) (Max dose: 20 mg/day) 10 to 17 years old Initial:2.5 mg of oral olanzapine and 20 mg of oral fluoxetine once daily (Max dose: 12 mg olanzapine / 5

DOSING GUIDE Dose titration: Increment/decrement of 2.5 or 5 mg at Depressive episodes (in combination with fluoxetine)

MEDICATION Olanzapine Oral Oral Quetiapine

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