Page 86 - e-book CPG - Bipolar Disorder

CLINICAL PRACTICE GUIDELINES MANAGEMENT OF BIPOLAR DISORDER (2ND ED.)

REMARKS adjustments may be  No specific FDA/ NPRA approved dose in children/adolescent population for use of risperidone LAI in bipolar disorder.*  In patients with persistent somnolence, administering half the daily dose twice daily may be beneficial.  Well accepted for treatment of behavioural

necessary. and fatigue

HEPATIC daily to effective dose based on individual clinical response and tolerability No pediatric-specific dosage recommendations Based on experience in adult patients, dosing adjustments suggested

No pediatric-specific dosage recommendations Based on experience in adult patients, dosing adjustments suggested 72
RENAL

DOSING GUIDE **Total daily doses may also be divided into 3 doses per (Usual dosage range: 400 - 600 mg once daily) Titrate in increment of 0.5 - 1 mg/day at intervals >24 **Doses >2.5mg/day do not confer additional benefit and are associated with increased adverse events

(Max dose: 600 mg/day) day Oral, extended release (ER) D1: 50 mg once daily D2: 100 mg once daily D3: 200 mg once daily D4: 300 mg oce daily D5: 400 mg once daily (Max dose: 600 mg/day) Mania 10 to 17 years old Oral Initial: 0.5 mg once daily hours Usual target dose: 1 - 2.5 mg

MEDICATION Risperidone Ziprasidone

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