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Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

Uses: Antiseptic & expectorant

2- 1,8-Cineol (Eucalyptol)

Source:
• Eucalyptus oil,
O
• Resemary oil

• commom sage oil

Uses:

• Expectorant, diuretic, antiseptic, antispasmodic

• Prevent calculus formation in kidney or even help in dissolving the already formed
calculus either in kidney or gall bladder.

• Ingredient in many brands of mouth wash and cough suppressant

• Insecticide and insect repellent

IV- Terpene Peroxide

1- Ascaridole

• Occurrence: In Chenopodium oil
• Preparation: by fractional distillation under reduced pressure WHY??? (to
O
avoid explosion)
O
• Characters: viscous yellow liquid with nasty disagreable odour & taste.
• Test:
+2
Ascaridole • Give blood red color with Fe + ammonium thiocyanate.
• Uses: Anthelmintic for round & hook worms
OH

O o
+ 2HI + I 2
O o

Ascaridol OH

• Estimation: (Iodometrically: based on the oxidizing action of peroxides), the oil +

acidified KI solution & the liberated I is titrated against standard Na S O solution.
2 2 2 3
• N.B.
– Blank experiment should be carried out
– Temperature must be low to avoid addition of I to the double bond
2
and volatilization of I
2
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