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PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(

‒ Binding to tissue proteins:

Many drugs accumulate in tissues at higher concentrations than those in the

extracellular fluids and blood which is called localization

‒ Significance:

▪ Firstly, it increases the apparent volume of distribution (in contrast to plasma

protein binding which decreases it).

▪ Secondly it results in localization of a drug at a specific site in the body

producing local toxicity.

Drug local toxicity

Aminoglycoside antibiotic gentamicin Nephro and vestibular toxicity

Chlorpromazine, chloroquine Retinopathy

Tetracyclines, fluoride permanent brown-yellow discoloration
of teeth.
(infants or children) during
odontogenesis

Paracetamol and chloroform Hepatotoxicity
metabolites

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