Page 91 - Interactive Theoritical Notes of Bioharmaceutics and pharamcokinetics.docx compressed

PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(

• P-gp is extensively distributed and expressed
▪ P-gp is expressed also in other tissues such as the blood–brain barrier,

liver, and kidney, where it limits drug penetration into the brain,
mediates biliary drug secretion, and mediates renal tubular drug

secretion, respectively.

▪ Efflux pumps are present throughout the body and are involved in

transport of a diverse group of hydrophobic drugs, natural products,

and peptides.

▪ Many drugs such as cyclosporin A, verapamil, terfenadine,

fexofenadine, and most HIV-1 protease inhibitors, are substrates of P-

gp

3. Vesicular Transport

• Vesicular transport is the process of engulfing particles or dissolved materials by

the cell.

• Pinocytosis and phagocytosis are forms of vesicular transport that differ by the

type of material ingested

Endocytosis and exocytosis are the processes of moving specific

macromolecules into and out of a cell, respectively

90