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DE/H/3682/001/IA/020_approved_common_SPC

               Metabolism    Timolol                                                                hypoglycaemia
               and           maleate   eye
               nutrition     drops, solution
               disorders
               Psychiatric   Timolol                                   depression*   insomnia*,     hallucination
               disorders     maleate   eye                                           nightmares*,
                             drops, solution                                         memory loss
               Nervous       Dorzolamide                headache*                    dizziness*,
               system        hydrochloride                                           paraesthesia*
               disorders     eye     drops,
                             solution
                             Timolol                    headache*      dizziness*,   paraesthesia*,
                             maleate   eye                             syncope*      increase   in
                             drops, solution                                         signs     and
                                                                                     symptoms of
                                                                                     myasthenia
                                                                                     gravis,
                                                                                     decreased
                                                                                     libido*,
                                                                                     cerebrovascul
                                                                                     ar accident*,
                                                                                     cerebral
                                                                                     ischaemia
               Eye           Combined        burning    conjunctival
               disorders     dorzolamide/ti  and        injection,
                             molol           stinging   blurred
                             preservative               vision,
                             free                       corneal
                             formulation                erosion,

                                                        ocular
                                                        itching,
                                                        tearing
                             Dorzolamide                eyelid         iridocyclitis*   irritation   foreign  body
                             hydrochloride              inflammation                  including     sensation in eye
                             eye     drops,             *,                            redness*,
                             solution                   eyelid                        pain*,
                                                        irritation*                   eyelid
                                                                                      crusting*,
                                                                                      transient
                                                                                      myopia
                                                                                      (which
                                                                                      resolved
                                                                                      upon
                                                                                      discontinuati
                                                                                      on        of
                                                                                      therapy),
                                                                                      corneal
                                                                                      œdema*,
                                                                                      ocular
                                                                                      hypotony*,
                                                                                      choroidal
                                                                                      detachment
                                                                                                       9
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