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DE/H/3682/001/IA/020_approved_common_SPC

                                                                                      (following
                                                                                      filtration
                                                                                      surgery)*
                             Timolol                    signs    and visual          ptosis,        itching,

                             maleate   eye              symptoms of  disturbances    diplopia,      tearing,
                             drops, solution            ocular         including     choroidal      redness,
                                                        irritation     refractive    detachment
                                                        including      changes (due   following     blurred vision,
                                                        blepharitis*,   to           filtration     corneal erosion
                                                        keratitis*,    withdrawal    surgery* (see
                                                        decreased      of miotic     Special
                                                        corneal        therapy in    warning  and
                                                                       some cases)*
                                                        sensitivity,                 precautions
                                                        and dry eyes*                for use 4.4)
               Ear     and Timolol                                                   tinnitus*
               labyrinth     maleate   eye
               disorders     drops, solution
               Cardiac       Timolol                                   bradycardia*  chest  pain*, atrioventricular
               disorders     maleate   eye                                           palpitation*,   block,
                             drops, solution                                         oedema*,       cardiac failure

                                                                                     arrhythmia*,
                                                                                     congestive
                                                                                     heart failure*,
                                                                                     cardiac
                                                                                     arrest*,
                                                                                     heart block
                             Dorzolamide                                                            palpitations,
                             hydrochloride                                                          tachycardia
                             eye     drops,
                             solution
               Vascular      Dorzolamide                                                            hypertension
               disorders     hydrochloride
                             eye     drops,
                             solution
                             Timolol                                                 hypotension*,
                             maleate   eye                                           claudication,
                             drops, solution                                         Raynaud’s

                                                                                     phenomenon*,
                                                                                     cold    hands
                                                                                     and feet*
               Respiratory,  Combined                   sinusitis                    shortness  of
               thoracic,     dorzolamide/ti                                          breath,
               and           molol                                                   respiratory
               mediastinal   preservative                                            failure,
               disorders     free                                                    rhinitis,
                             formulation
                                                                                     rarely
                                                                                     bronchospasm
                             Dorzolamide                                             epistaxis*     dyspnoea
                             hydrochloride
                             eye     drops,
                             solution

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