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EFFICACY

Eye (2012) 26, 80–87
& 2012 Macmillan Publishers Limited All rights reserved 0950-222X/12
www.nature.com/eye

Twenty-four hour AGP Konstas , L Quaranta , DB Yan , 3
1
2
3
1
2
DG Mikropoulos , I Riva , NK Gill , K Barton 4
efficacy with the and A-B Haidich 5
dorzolamide/
timolol-fixed
CLINICAL
combination
compared with the
STUDY
brimonidine/
timolol-fixed
combination in
primary open-angle

glaucoma

1
Glaucoma Unit,
1st University Department Abstract Conclusion Both the fixed combinations
of Ophthalmology, AHEPA
Hospital, Thessaloniki, Aim The aim of this study is to compare the significantly reduce 24-hour IOP in POAG.
Greece 24-hour efficacy of dorzolamide/timolol-fixed DTFC provided significantly better 24-hour
combination (DTFC) and brimonidine/ efficacy.
2
Center for the Study of Eye (2012) 26, 80–87; doi:10.1038/eye.2011.239;
Glaucoma, University of timolol-fixed combination (BTFC) in primary published online 30 September 2011
Brescia, Brescia, Italy open-angle glaucoma (POAG).
Methods One eye each of 77 POAG
Keywords: dorzolamide/timolol; brimonidine/
3 University of Toronto, patients was included in this prospective,
Toronto, Canada observer-masked, crossover comparison. timolol; 24-hour IOP; POAG
Following a 2-month timolol run-in period,
4
Glaucoma Service, patients had three intraocular pressure (IOP)
Moorfields Eye Hospital, Introduction
London, UK measurements at 1000, 1200 and 1400 h while
on timolol treatment. Patients showing at least Orally administered fixed-dose combinations
5 a 20% IOP reduction on timolol were have been shown to improve adherence to
Department of Hygiene,
Aristotle University randomised to 3 months of therapy with DTFC chronic medical therapy. 1–4 It is known that
of Thessaloniki, or BTFC, and then were crossed over to the almost half of the patients with chronic,
Thessaloniki, Greece opposite therapy. asymptomatic diseases do not take their
Results Sixty POAG patients completed the medications as prescribed. 5–8 In medicine,
Correspondence: study. The mean 24-hour IOP was significantly
AGP Konstas, Glaucoma a recent meta-analysis showed that non-
Unit, 1st University reduced with both the fixed combinations adherence to medical therapy is reduced by
Department of compared with the timolol-treated diurnal IOP 24–26% with fixed-dose combination regimens
Ophthalmology, AHEPA (Po0.001). When the two fixed combinations compared with unfixed concomitant therapies. 3
Hospital, 1 Kyriakidi Street, were compared directly, DTFC demonstrated a Fixed combinations of glaucoma medications, in
Thessaloniki 546 36, Greece
Tel: þ 30 2310 994 774; lower mean 24-hour IOP level as compared most cases, provide similar intraocular pressure
Fax: þ 30 2310 952 800. with BTFC (mean difference: �0.7 mm Hg, 95% (IOP) reduction to that observed with
E-mail: konstas@ confidence interval (CI): (�1.0, �0.3), Po0.001). simultaneous administration of their individual
med.auth.gr At two individual time points, DTFC components, 1,9 simplify adjunctive medication
significantly reduced IOP more than BTFC: at regimens, 10,11 reduce the incidence of adverse
Received: 29 June 2011 1800 h (�1.0 mm Hg, 95% CI (�1.6,�0.5), events, 12,13 and may improve adherence and
Accepted in revised form: P ¼ 0.001) and at 0200 (�0.9 mm Hg, 95% CI: 1,12,14
9 August 2011 long-term tolerability.
Published online: 30 (�1.4,�0.5), P ¼ 0.001). No significant The dorzolamide/timolol-fixed combination
September 2011 difference existed for the other time points. (DTFC, Cosopt) and the brimonidine/timolol-fixed

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