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Intravascular Mesenchymal Stem Cells to Treat Organ Failure and Possible Application in COVID-19
Decreases SOFA score. All survived and 1 out of 7 in the control survived. LSI score QOL indicators. Length of hospital stay, ventilator-free days, and ICU-free days at day 28 after FiO2 did not improve. volumes, and compliance. Mean LSI and SOFA scores highest decline in the high- dose group. Mortality rate moderate ARDS. Higher mortality in the MSC at baseline. SOFA scores not reported in the study. FEV-1 and FVC at 3 weeks.
Findings patients in the treatment group improved in the treatment group. No differences in frequency of COPD exacerbations, PFTs, or treatment were similar. PaO2/ Improved lung function, tidal Resolution of multiorgan failure and discharge from the hospital. declined with all doses with the (22%) lower than the expected mortality (32%) in patients with group, however, not statistically significant. The MSC group had sicker patients represen
Follow-Up 15 days 2 years 28 days NA 60 days 12 months 12 months
Condition Acute lung injury COPD ARDS ARDS ARDS ARDS COPD
Outcome Yes No No Yes Yes No Yes
Delivery Method IV IV IV IV IV IV IV
Type of Stem Cell UCB Allo BM MSC Allo Adipose BM MSC Allo BM MSC Allo BM MSC Allo BM MSC [Pas 3]
Number of MSC 1 million 100 million x 4 doses 1 million 2 million 1, 5, 10 million 1, 5, 10 million 2 million x 2 doses
BMA (mL) NA NA NA 28 NA 100 NA
Table 1. MSC therapy studies treating pulmonary failure.
Number of Patients in the Treatment Group 5 62 12 2 9 40 9
Type of Study PCT RCT RCT Case series Case series RCT Case series
Year 2012 2013 2014 2015 2015 2018 2018
Author Liu et al, Chin J Ind Hyg Occup Dis 2012; 30:811-815 Weiss et al, Chest 2013; 143:1590- 1598 Zheng et al, Respir Res 2014; 15:39 Simonson et al, Stem Cells Transl Med 2015; 4:1199-213 Wilson et al, Lancet Respir Med 2015; 3:24-32 Matthay et al, Lancet Respir Med 2019; 7:154-162 Armitage et al, Eur Respir J 2018; 51:1702369
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