Page 31 - PC 101 practical notes 24-25..

MANSOURA NATIONAL UNIVERSIY
PHARM D- CLINICAL PHARMACY LEVEL I PHARM. ANAL. CHEM. I (PC 101)

B B) ) D De et te er rm mi in na at ti io on n o of f N NH H4C Cl l s sa am mp pl le e b by y f fo or rm mo ol l m me et th ho od d
4

P Pr ri in nc ci ip pl le e : :

⎯→
4 NH 4Cl + 6 HCHO  (CH 2) 6N 4 + 4 HCl + 6 H 20
(sample) neutral Hexamine
formalin or Equivalent
Hexamethylene to NH4Cl
tetramine sample

It depends upon the addition of HCHO to the ammonium salt resulting

in the formation of Hexamine (Hexamethylene tetramine) in addition to

an amount of HCl equivalent to the sample analysed. Then the produced HCl is

titrated ≠ standard NaOH using ph.ph. indicator.

⎯
4 HCl + 4 NaOH ⎯→ 4 NaCl + 4 H 2O

 4 NH 4Cl ≡ 4 HCl ≡ 4 NaOH

Explanation

Demonstration

of the

experiment

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