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Immune Compatibility by Design

In conventional biologics, immune rejection is an ongoing
challenge. Proteins delivered via injection or infusion often
provoke the immune system, triggering anti-drug
antibodies (ADAs) that neutralize efficacy and, in some
cases, create dangerous inflammatory reactions. Entire
biologic classes have been derailed by these immune
complications.

Plant-based oral delivery takes a different approach: don’t
fight the immune system—cooperate with it.

When a protein is delivered orally, embedded in a food-like
matrix, it interacts with the gut’s tolerance mechanisms—
not its threat detectors.

The result?

• Lower ADA formation
• Reduced immune activation
• Higher likelihood of immune silence or even
regulatory T cell engagement

This makes edible biologics ideal for:

• Chronic conditions requiring long-term exposure
• Tolerizing therapies for autoimmune diseases
• Early-life intervention where immune training
matters most

It’s not just better delivery.
It’s immune pedagogy—teaching the immune system to
coexist with the therapy.

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