Page 229 - Binder2

Antibod Plant Key
Target Example /
Indication y Format Platfor Findings /
Antigen Reference
/ Source m Rationale
Transglutamin before (preclinical);
ase (tTG) epithelial Frontiers in
absorption; Immunology,
reduces 2021
antigen
presentatio
n to T cells
Provides
pathogen-
neutralizin Virdi et al.,
E. coli LT/ST g PNAS, 2019
Traveler’s toxins, Oral IgY Duckwe protection (anti-EHEC
Diarrhea / Shigella, or ed / at the sIgA in
Enteric Norovirus secretory Lettuce mucosal lettuce); IgY-
Infections IgA
capsid proteins surface based enteric
without models
systemic
side effects
Mucosal
antibodies Daniell et al.,
block viral Nature, 2021
Respiratory SARS-CoV-2 Buccal/or
Viruses spike, al sIgA Rice / entry at (oral anti-
COVID
upper
(e.g., Influenza or Lettuce / respiratory lettuce);
COVID-19, hemagglutinin, nanobody Tobacco
RSV) RSV F protein formats tract; safe Greenovatio
for at-risk n Biotech
or pediatric (RSV IgG)
use

227