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• Myelin basic protein in multiple sclerosis
• Gliadin peptides in celiac disease
• Environmental allergens like dust mites or peanut
proteins

Instead of suppressing immune function broadly, tolerizing
vaccines aim to restore balance through targeted immune
tolerance.
And plant-based systems offer a uniquely powerful way to
deliver that message.

The Immunologic Blueprint: Re-educating T Cells

The key to tolerance induction lies in the
microenvironment of antigen exposure.

When an antigen is introduced:

• At high doses, via injection, or alongside
inflammatory signals, the immune system
interprets it as dangerous—activating effector T
cells, cytokine cascades, and often leading to
chronic inflammation or antibody production.

But when an antigen is introduced:

• Orally, in low, steady doses, and without
inflammation—it is more likely to activate
regulatory T cells (Tregs), which suppress
overactive immune responses and restore
homeostasis.

This process happens most effectively in specialized
immune tissues in the gut, particularly:

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